German Shepherd: degenerative myelopathy (SOD1) and mobility gear
An older German Shepherd that drags its rear nails on the floor, crosses its paws or struggles to get up isn't necessarily dealing with "old hips": these signs point to a well-documented degenerative neurological disease whose genetic cause is now identified. Find all our health guidance in the dog care and grooming section.
What the landmark study shows
Awano and colleagues published a genome-wide association analysis in 2009 in the Proceedings of the National Academy of Sciences that revealed a SOD1 gene mutation responsible for canine degenerative myelopathy, a disease that resembles human amyotrophic lateral sclerosis (study on Google Scholar). The authors describe a progressive breakdown of the spinal cord's nerve pathways, beginning around eight years of age or later with weakness and loss of coordination in the hind limbs, painless at first. The mutation, found in several breeds including the German Shepherd, is inherited recessively: a DNA test now distinguishes clear, carrier and at-risk dogs.
Supporting a dog losing its hind legs
- A support harness with a handle, to help the dog stand and get into the car without straining its rear end.
- Non-slip mats on smooth floors, since loss of coordination makes tile especially treacherous.
- Protective boots, when the dog wears down its nails or the top of its paws by scuffing the floor.
To make moving around the house easier, our guide to the dog ramp or stairs and the one on senior dog everyday equipment cover the essentials. Preserving muscle mass also runs through diet: see our omega-3 and glucosamine supplements. Find the full breed profile on the German Shepherd page.
Frequently asked questions
Will an "at-risk" dog definitely develop the disease?
No: the at-risk genotype is necessary but not every dog that carries it develops the disease, which is why the test should be interpreted with a vet.
Is degenerative myelopathy painful?
It is painless in its early stages, which sets it apart from arthritis; it is precisely the lack of pain combined with loss of coordination that should raise a flag.
Can its progression be slowed?
There is no cure, but suitable physical activity and physiotherapy help preserve mobility for as long as possible.
This guide is part of Planète Pets’s Dogs universe. Our advice is general in nature: for any health concern, your veterinarian remains the only reference.